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g inalliance。 that鈥檚 why it is so hard to work out how it all fits together and why we won鈥檛 beproducing designer babies anytime soon。
in fact； the more we have learned in recent years the more plicated matters have tendedto bee。 even thinking； it turns out； affects the ways genes work。 how fast a man鈥檚 beard grows； for instance； is partly a function of how much he thinks about sex （because thinkingabout sex produces a testosterone surge）。 in the early 1990s； scientists made an even moreprofound discovery when they found they could knock out supposedly vital genes fromembryonic mice； and the mice were not only often born healthy； but sometimes were actuallyfitter than their brothers and sisters who had not been tampered with。 when certain importantgenes were destroyed； it turned out； others were stepping in to fill the breach。 this wasexcellent news for us as organisms； but not so good for our understanding of how cells worksince it introduced an extra layer of plexity to something that we had barely begun tounderstand anyway。
it is largely because of these plicating factors that cracking the human genome becameseen almost at once as only a beginning。 the genome； as eric lander of mit has put it； is likea parts list for the human body： it tells us what we are made of； but says nothing about howwe work。 what鈥檚 needed now is the operating manual鈥攊nstructions for how to make it go。
we are not close to that point yet。
so now the quest is to crack the human proteome鈥攁 concept so novel that the termproteome didn鈥檛 even exist a decade ago。 the proteome is the library of information thatcreates proteins。 鈥渦nfortunately；鈥潯bserved scientific american in the spring of 2002； 鈥渢heproteome is much more plicated than the genome。鈥�
that鈥檚 putting it mildly。 proteins； you will remember； are the workhorses of all livingsystems； as many as a hundred million of them may be busy in any cell at any moment。 that鈥檚a lot of activity to try to figure out。 worse； proteins鈥櫋ehavior and functions are based notsimply on their chemistry； as with genes； but also on their shapes。 to function； a protein mustnot only have the necessary chemical ponents； properly assembled； but then must also befolded into an extremely specific shape。 鈥渇olding鈥潯s the term that鈥檚 used； but it鈥檚 amisleading one as it suggests a geometrical tidiness that doesn鈥檛 in fact apply。 proteins loopand coil and crinkle into shapes that are at once extravagant and plex。 they are more likefuriously mangled coat hangers than folded towels。
moreover； proteins are （if i may be permitted to use a handy archaism） the swingers of thebiological world。 depending on mood and metabolic circumstance； they will allowthemselves to be phosphorylated； glycosylated； acetylated； ubiquitinated； farneysylated；sulfated； and linked to glycophosphatidylinositol anchors； among rather a lot else。 often ittakes relatively little to get them going； it appears。 drink a glass of wine； as scientificamerican notes； and you materially alter the number and types of proteins at large in yoursystem。 this is a pleasant feature for drinkers； but not nearly so helpful for geneticists who aretrying to understand what is going on。
it can all begin to seem impossibly plicated； and in some ways itis impossiblyplicated。 but there is an underlying simplicity in all this； too； owing to an equallyelemental underlying unity in the way life works。 all the tiny； deft chemical processes thatanimate cells鈥攖he cooperative efforts of nucleotides； the transcription of dna into rna鈥攅volved just once and have stayed pretty well fixed ever since across the whole of nature。 asthe late french geneticist jacques monod put it； only half in jest： 鈥渁nything that is true of e。
coli must be true of elephants； except more so。鈥�
every living thing is an elaboration on a single original plan。 as humans we are mereincrements鈥攅ach of us a musty archive of adjustments； adaptations； modifications； andprovidential tinkerings stretching back 3。8 billion years。 remarkably； we are even quite closely related to fruit and vegetables。 about half the chemical functions that take place in abanana are fundamentally the same as the chemical functions that take place in you。
it cannot be said too often： all life is one。 that is； and i suspect will forever prove to be； themost profound true statement there is。
part vithe road to usdescended from the apes！ my dear；let us hope that it is not true； but if it is；let us pray that it will not beegenerally known。
…remark attributed to the wife ofthe bishop of worcester afterdarwin鈥檚 theory of evolution was explained to her
w w w。 xiao shuotxt。 co m
27 ICE TIME
灏彙〃t：xt。。澶″爞
i had a dream； which was notall a dream。
the bright sun wasextinguish鈥檇； and the starsdid wander 。 。 。
鈥攂yron； 鈥渄arkness鈥�
in 1815 on the island of sumbawa in indonesia； a handsome and long…quiescent mountainnamed tambora exploded spectacularly； killing a hundred thousand people with its blast andassociated tsunamis。 it was the biggest volcanic explosion in ten thousand years鈥�150 timesthe size of mount st。 helens； equivalent to sixty thousand hiroshima…sized atom bombs。
news didn鈥檛 travel terribly fast in those days。 in london； the times ran a small story鈥攁ctually a letter from a merchant鈥攕even months after the event。 but by this time tambora鈥檚effects were already being felt。 thirty…six cubic miles of smoky ash； dust； and grit haddiffused through the atmosphere； obscuring the sun鈥檚 rays and causing the earth to cool。
sunsets were unusually but blearily colorful； an effect memorably captured by the artist j。 m。
w。 turner； who could not have been happier； but mostly the world existed under anoppressive； dusky pall。 it was this deathly dimness that inspired the byron lines above。
spring never came and summer never warmed： 1816 became known as the year withoutsummer。 crops everywhere failed to grow。 in ireland a famine and associated typhoidepidemic killed sixty…five thousand people。 in new england； the year became popularlyknown as eighteen hundred and froze to death。 morning frosts continued until june andalmost